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(Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate_Molecular_structure_CAS_190849-64-0)
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(Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate

Catalog No. 12792 Name Sigma Aldrich
CAS Number 190849-64-0 Website http://www.sigmaaldrich.com
M. F. C17H24F6N5OP Telephone 1-800-521-8956
M. W. 459.3695402 Fax
Purity ≥98.0% (TLC) Email
Storage Chembase ID: 150079

SYNONYMS

Title
(苯并三氮唑-1-基氧基)二哌啶碳鎓六氟磷酸盐
IUPAC name
(1H-1,2,3-benzotriazol-1-yloxy)bis(piperidin-1-yl)methylium; hexafluoro-λ5-phosphanuide
IUPAC Traditional name
(1,2,3-benzotriazol-1-yloxy)bis(piperidin-1-yl)methylium hexafluorophosphate
Synonyms
HBPipU
O-(Benzotriazol-1-yl)-N,N,N′,N′-bis(pentamethylene)uronium hexafluorophosphate
O-苯并三唑-1-基-N,N,N',N'-二(五亚甲基)六氟磷酸脲

DATABASE IDS

PubChem SID 24847806
CAS Number 190849-64-0
MDL Number MFCD00191769

PROPERTIES

Empirical Formula (Hill Notation) C17H24F6N5OP
Purity ≥98.0% (TLC)
Melting Point 206 °C (dec.)
Solubility acetonitrile: soluble0.1 g/mL, clear
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
Safety Statements 26-36
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (简体中文)
Other Notes
最近的研究显示该偶联试剂的晶体和溶液结构为胍的 N-氧化物形式,而不是脲化合物3;肽偶联反应的不吸湿强烈反应剂。这是最近报道的双(四亚甲基)衍生物的类似物4
包装
5 g in glass bottle
Application
Reactant used for: comparison of racemization during peptide coupling1 esterification of nucleosides to solid phase supports for oligonucleotide synthesis2
Description (English)
Other Notes
Recent studies show that crystal and solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound3; Non-hygroscopic, extremely reactive reagent for peptide coupling. It is an analogue of the bis(tetramethylene) derivative described recently4
Packaging
5 g in glass bottle
Application
Reactant used for: comparison of racemization during peptide coupling1 esterification of nucleosides to solid phase supports for oligonucleotide synthesis2

REFERENCES