(Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate

• Catalog No.: 12792
• CAS Number: 190849-64-0
• M. F.: C17H24F6N5OP
• M. W.: 459.3695402
• Purity: ≥98.0% (TLC)

SYNONYMS

• Title: (苯并三氮唑-1-基氧基)二哌啶碳鎓六氟磷酸盐
• IUPAC name: (1H-1,2,3-benzotriazol-1-yloxy)bis(piperidin-1-yl)methylium; hexafluoro-λ^5-phosphanuide
• IUPAC Traditional name: (1,2,3-benzotriazol-1-yloxy)bis(piperidin-1-yl)methylium hexafluorophosphate
• Synonyms: HBPipU; O-(Benzotriazol-1-yl)-N,N,N′,N′-bis(pentamethylene)uronium hexafluorophosphate; O-苯并三唑-1-基-N,N,N',N'-二(五亚甲基)六氟磷酸脲

DATABASE IDS

• PubChem SID: 24847806
• CAS Number: 190849-64-0
• MDL Number: MFCD00191769

PROPERTIES

• Empirical Formula (Hill Notation): C17H24F6N5OP
• Purity: ≥98.0% (TLC)
• Melting Point: 206 °C (dec.)
• Solubility: acetonitrile: soluble0.1 g/mL, clear
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Other Notes
最近的研究显示该偶联试剂的晶体和溶液结构为胍的 N-氧化物形式，而不是脲化合物3；肽偶联反应的不吸湿强烈反应剂。这是最近报道的双(四亚甲基)衍生物的类似物4
包装
5 g in glass bottle
Application
Reactant used for: comparison of racemization during peptide coupling1 esterification of nucleosides to solid phase supports for oligonucleotide synthesis2

Description (English)

Other Notes
Recent studies show that crystal and solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound3; Non-hygroscopic, extremely reactive reagent for peptide coupling. It is an analogue of the bis(tetramethylene) derivative described recently4
Packaging
5 g in glass bottle
Application
Reactant used for: comparison of racemization during peptide coupling1 esterification of nucleosides to solid phase supports for oligonucleotide synthesis2