Acetylcholine chloride

• Catalog No.: 01018
• CAS Number: 60-31-1
• M. F.: C7H16ClNO2
• M. W.: 181.66044
• Purity: ≥99.0% (AT)

SYNONYMS

• Title: 氯化乙酰胆碱
• IUPAC name: [2-(acetyloxy)ethyl]trimethylazanium chloride
• IUPAC Traditional name: acetylcholine chloride
• Synonyms: ACh

DATABASE IDS

• Beilstein Number: 3571875
• CAS Number: 60-31-1
• MDL Number: MFCD00011698
• EC Number: 200-468-8

PROPERTIES

• Cation Traces: Ca: ≤20 mg/kg
• Cation Traces: Cd: ≤5 mg/kg
• Cation Traces: Co: ≤5 mg/kg
• Cation Traces: Cr: ≤5 mg/kg
• Cation Traces: Cu: ≤5 mg/kg
• Cation Traces: Fe: ≤5 mg/kg
• Cation Traces: K: ≤50 mg/kg
• Cation Traces: Mg: ≤5 mg/kg
• Cation Traces: Mn: ≤5 mg/kg
• Cation Traces: Na: ≤50 mg/kg
• Cation Traces: Ni: ≤5 mg/kg
• Cation Traces: Pb: ≤5 mg/kg
• Cation Traces: Zn: ≤5 mg/kg
• Ignition Residue: ≤0.05%
• Linear Formula: (CH3)3N+CH2CH2OCOCH3Cl-
• Purity: ≥99.0% (AT)
• Suitability: suitable as substrate for acetylcholinesterase test
• Melting Point: 146-150 °C(lit.)
• Melting Point: 148-150 °C
• Solubility: H2O: soluble0.1 g/mL, clear, colorless
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: FZ9800000
• Safety Statements: 26
• German water hazard class: 2

DETAILS

Description (English)

Other Notes
Hydrolysis by acetylcholinesterase2; Base-catalysed hydrolysis in the presence of surfactants3; Kinetic parameters of acetylcholinesterase-catalyzed hydrolysis4
Biochem/physiol Actions
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis 1. The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Description (简体中文)

Other Notes
Hydrolysis by acetylcholinesterase2; Base-catalysed hydrolysis in the presence of surfactants3; Kinetic parameters of acetylcholinesterase-catalyzed hydrolysis4
Biochem/physiol Actions
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis 1. The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.