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Acetylcholine chloride

Catalog No. 01018 Name Sigma Aldrich
CAS Number 60-31-1 Website http://www.sigmaaldrich.com
M. F. C7H16ClNO2 Telephone 1-800-521-8956
M. W. 181.66044 Fax
Purity ≥99.0% (AT) Email
Storage Chembase ID: 53477

SYNONYMS

Title
氯化乙酰胆碱
IUPAC name
[2-(acetyloxy)ethyl]trimethylazanium chloride
IUPAC Traditional name
acetylcholine chloride
Synonyms
ACh

DATABASE IDS

Beilstein Number 3571875
CAS Number 60-31-1
MDL Number MFCD00011698
EC Number 200-468-8

PROPERTIES

Cation Traces Ca: ≤20 mg/kg
Cation Traces Cd: ≤5 mg/kg
Cation Traces Co: ≤5 mg/kg
Cation Traces Cr: ≤5 mg/kg
Cation Traces Cu: ≤5 mg/kg
Cation Traces Fe: ≤5 mg/kg
Cation Traces K: ≤50 mg/kg
Cation Traces Mg: ≤5 mg/kg
Cation Traces Mn: ≤5 mg/kg
Cation Traces Na: ≤50 mg/kg
Cation Traces Ni: ≤5 mg/kg
Cation Traces Pb: ≤5 mg/kg
Cation Traces Zn: ≤5 mg/kg
Ignition Residue ≤0.05%
Linear Formula (CH3)3N+CH2CH2OCOCH3Cl-
Purity ≥99.0% (AT)
Suitability suitable as substrate for acetylcholinesterase test
Melting Point 146-150 °C(lit.)
Melting Point 148-150 °C
Solubility H2O: soluble0.1 g/mL, clear, colorless
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
RTECS FZ9800000
Safety Statements 26
German water hazard class 2

DETAILS

Description (English)
Other Notes
Hydrolysis by acetylcholinesterase2; Base-catalysed hydrolysis in the presence of surfactants3; Kinetic parameters of acetylcholinesterase-catalyzed hydrolysis4
Biochem/physiol Actions
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis 1. The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Description (简体中文)
Other Notes
Hydrolysis by acetylcholinesterase2; Base-catalysed hydrolysis in the presence of surfactants3; Kinetic parameters of acetylcholinesterase-catalyzed hydrolysis4
Biochem/physiol Actions
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis 1. The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

REFERENCES