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Dronabinol

Catalog No. DB00470 Name DrugBank
CAS Number 1972-08-3 Website http://www.ualberta.ca/
M. F. C21H30O2 Telephone (780) 492-3111
M. W. 314.4617 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 353

SYNONYMS

IUPAC name
(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol
IUPAC Traditional name
marinol
Brand Name
Marinol
Dronabinol [Usan:Inn]
Dea No. 7369
Deltanyne
Abbott 40566
Dea No. 7370
Dronabinol
Dronabinolum [Latin]
&Delta
9-tetrahydrocannabinol
9-THC
delta-9-tetrahydrocannabinol
delta-9-THC

DATABASE IDS

PubChem CID 16078
CAS Number 1972-08-3
PubChem SID 46508472

PROPERTIES

Hydrophobicity(logP) 5.648
Solubility 2.8 mg/ml

DETAILS

Description (English)
Item Information
Drug Groups illicit; approved
Description A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. Dronabinol is a synthetic form of delta-9-THC. [PubChem]
Indication For the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments
Pharmacology Marinol may has complex effects on the central nervous system (CNS), including cannabinoid receptors. Dronabinol may inhibit endorphins in the emetic center, suppress prostaglandin synthesis, and/or inhibit medullary activity through an unspecified cortical action.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Absorption 90 - 95%
Half Life Alpha phase: approximately 4 hours; Beta phase: 25-36 hours
Protein Binding 97%
Elimination Dronabinol and its biotransformation products are excreted in both feces and urine.
Distribution * 10 L/kg
Clearance * 0.2 L/kg-hr
External Links
Wikipedia
RxList

REFERENCES