Lawesson reagent

• Catalog No.: 61750
• CAS Number: 19172-47-5
• M. F.: C14H14O2P2S4
• M. W.: 404.467282
• Purity: ≥98.0% (S)

SYNONYMS

• Title: Lawesson 试剂
• IUPAC name: bis(4-methoxyphenyl)-1,3,2λ^5,4λ^5-dithiadiphosphetane-2,4-dithione
• IUPAC Traditional name: lawesson's reagent
• Synonyms: LR; 2,4-Bis(4-methoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane; 2,4-Bis-(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide; 4-Methoxyphenylthiophosphoric cyclic di(thioanhydride); 4-甲氧基苯基硫代磷环二(硫代酸酐)

DATABASE IDS

• CAS Number: 19172-47-5
• Beilstein Number: 1024888
• EC Number: 242-855-4
• MDL Number: MFCD00005171
• PubChem SID: 24874849

PROPERTIES

• Empirical Formula (Hill Notation): C14H14O2P2S4
• Grade: purum
• Purity: ≥98.0% (S)
• Melting Point: 228-230 °C(lit.)
• Melting Point: 228-230 °C
• GHS Signal Word: Danger
• GHS Hazard statements: H261
• European Hazard Symbols: Flammable (F)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• GHS Precautionary statements: P231 + P232-P422
• Risk Statements: 15/29
• Safety Statements: 7/8-43
• Supplemental Hazard Statements: Contact with water liberates toxic gas.
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
The most efficient thiation reagent known till now, used for the thiation of carboxamides, ketones, lactones and imides, lactames, 3-oxocarboxylic derivatives (amides, esters and nitriles) and thio-S-esters1; Selective thionation of oligopeptides2,3; Reviews about LR4,5

Description (简体中文)

Other Notes
目前所知的最有效硫杂化反应试剂，用于羧酰胺、酮、内酯和亚胺、内酰胺、3-氧代羧基衍生物（酰胺、酯和腈）以及硫代-S-酯的硫杂化反应1；寡肽的选择性硫化反应2,3；关于 LR 的综述4,5