Fmoc chloride

• Catalog No.: 23185
• CAS Number: 28920-43-6
• M. F.: C15H11ClO2
• M. W.: 258.69964
• Purity: ≥98.0% (HPLC)

SYNONYMS

• Title: 氯甲酸-9-芴基甲酯
• IUPAC name: 9H-fluoren-9-ylmethyl chloroformate
• IUPAC Traditional name: 9H-fluoren-9-ylmethyl chloroformate
• Synonyms: 9-Fluorenylmethyl chloroformate; 9-Fluorenylmethoxycarbonyl chloride; 9-芴甲氧羰酰氯; 芴甲氧羰酰氯; FMOC-Cl

DATABASE IDS

• Beilstein Number: 2279177
• CAS Number: 28920-43-6
• EC Number: 249-313-6
• MDL Number: MFCD00001138
• PubChem SID: 24853862

PROPERTIES

• Empirical Formula (Hill Notation): C15H11ClO2
• Grade: purum
• Purity: ≥98.0% (HPLC)
• Melting Point: 61-63 °C
• Melting Point: 62-64 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H314
• European Hazard Symbols: Corrosive (C)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P280-P305 + P351 + P338-P310
• RID/ADR: UN 3261 8/PG 2
• Risk Statements: 34
• RTECS: LQ6250000
• Safety Statements: 26-36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 8
• UN Number: 3261
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Application
Reagent for derivatizing amino acids for HPLC amino acid analysis and for preparing N-Fmoc amino acids for solid-phase peptide synthesis.
Other Notes
For the introduction of the 9-fluorenylmethoxycarbonyl (Fmoc) amino-protecting group, which is stable towards acids and catalytic hydrogenation, but readily cleaved under mildly basic non-hydrolytic conditions1,2; Use of the Fmoc-group for the protection of hydroxy groups3; protection of amino groups in nucleotides4

Description (简体中文)

Application
在氨基酸 HPLC 分析中，用于衍生化氨基酸；在固相肽合成中用于制备 N-Fmoc 氨基酸。
Other Notes
用于引入氨基保护基团 9-芴甲氧羰基 (Fmoc)，Fmoc 对酸和催化氢化反应稳定，但在温和碱性非水解条件下易被裂解1,2；Fmoc 基团可用于保护羟基3；保护核苷酸中的氨基4