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Calcium Ionophore A23187_Molecular_structure_CAS_52665-69-7)
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Calcium Ionophore A23187

Catalog No. 21045 Name Sigma Aldrich
CAS Number 52665-69-7 Website http://www.sigmaaldrich.com
M. F. C29H37N3O6 Telephone 1-800-521-8956
M. W. 523.62058 Fax
Purity ~95% (HPLC) Email
Storage Chembase ID: 125569

SYNONYMS

Title
钙离子载体 A23187
IUPAC name
5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
IUPAC Traditional name
5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
Synonyms
Calimycin
钙离子载体
抗生素 A 23187
Antibiotic A 23187

DATABASE IDS

MDL Number MFCD00151202
EC Number 258-084-1
CAS Number 52665-69-7
Beilstein Number 1096801

PROPERTIES

Empirical Formula (Hill Notation) C29H37N3O6
Purity ~95% (HPLC)
Melting Point 187-190 °C
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
RTECS DM4676000
Safety Statements 26-36
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Application
Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.
Other Notes
A23187 increases the permeability of biological membranes with a high selectivity for Ca2+. It is used extensively in studies related to intracellular Ca2+,1,2,3
Description (简体中文)
Application
高选择性钙离子载体增强对 NMDA 非使君子氨酸的响应。在细胞培养中,通过钙调素依赖结构型一氧化氮合酶刺激一氧化氮的生成。
Other Notes
A23187 increases the permeability of biological membranes with a high selectivity for Ca2+. It is used extensively in studies related to intracellular Ca2+,1,2,3

REFERENCES