Actinomycin D

• Catalog No.: 01817
• CAS Number: 50-76-0
• M. F.: C62H86N12O16
• M. W.: 1255.41704
• Purity: ≥98.0% (HPLC)

SYNONYMS

• Title: 放线菌素 D
• IUPAC name: 1-N,9-N-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-bis(propan-2-yl)-hexadecahydro-1H-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
• IUPAC Traditional name: actinomycin D
• Synonyms: 更生霉素; Actinomycin C1; Actinomycin IV; Dactinomycin; 放线菌素 C1; 放线菌素 IV

DATABASE IDS

• CAS Number: 50-76-0
• Beilstein Number: 605235
• EC Number: 200-063-6
• MDL Number: MFCD00005033

PROPERTIES

• Biological Source: from Streptomyces sp.
• Empirical Formula (Hill Notation): C62H86N12O16
• Purity: ≥98.0% (HPLC)
• Apperance: red, powder
• Melting Point: 251-253
• Solubility: acetonitrile: soluble10 mg/mL, clear, orange to red
• GHS Signal Word: Danger
• GHS Hazard statements: H300
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P264-P301 + P310
• RID/ADR: UN 3462 6.1/PG 2
• Risk Statements: 28
• RTECS: AU1575000
• Safety Statements: 22-28-36/37-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Other Notes
Inhibits DNA-dependent RNA synthesis. DNA-binding drug1,2,3

Description (简体中文)

Biochem/physiol Actions
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Other Notes
Inhibits DNA-dependent RNA synthesis. DNA-binding drug1,2,3