Digoxin

• Catalog No.: 37100
• CAS Number: 20830-75-5
• M. F.: C41H64O14
• M. W.: 780.93846
• Purity: ≥95.0% (HPLC)

SYNONYMS

• Title: 地高辛
• IUPAC name: 4-[(1S,2S,5S,7R,10R,11S,14R,15S,16R)-5-{[(2R,4S,5S,6R)-5-{[(2S,4S,5S,6R)-5-{[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-11,16-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecan-14-yl]-2,5-dihydrofuran-2-one
• IUPAC Traditional name: digoxin
• Synonyms: 12β-Hydroxydigitoxin; 异羟基洋地黄毒苷

DATABASE IDS

• EC Number: 244-068-1
• PubChem SID: 24863090
• Beilstein Number: 77011
• CAS Number: 20830-75-5
• MDL Number: MFCD00003674

PROPERTIES

• Empirical Formula (Hill Notation): C41H64O14
• Ignition Residue: ≤0.1%
• Loss on Drying: ≤1% loss on drying, 110 °C
• Purity: ≥95.0% (HPLC)
• Gene Information: human ... ABCB1(5243), CYP3A4(1576)mouse ... Abcb1a(18671), Abcb1b(18669)rat ... Atp1a1(24211)
• Optical Rotation: [α]20/D +11.5±1.5°, c = 10% in pyridine
• GHS Signal Word: Danger
• GHS Hazard statements: H300 + H330
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P260-P264-P284-P301 + P310-P310
• RID/ADR: UN 3462 6.1/PG 2
• Risk Statements: 23/25
• RTECS: IH6125000
• Safety Statements: 22-36/37/39-45
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
A cardiac glycoside, substrate for Pgp, upregulates Pgp expression and down regulates SXR (Steroid Xenobiotic Receptor).

Description (简体中文)

Biochem/physiol Actions
一种强心苷，P-糖蛋白的底物，上调 Pgp 表达和下调 SXR（固醇类异生物受体）。