Diisopropylfluorophosphate

• Catalog No.: 38399
• CAS Number: 55-91-4
• M. F.: C6H14FO3P
• M. W.: 184.1457242
• Purity: ≥97.0% (GC)

SYNONYMS

• Title: 氟磷酸二异丙酯
• IUPAC name: bis(propan-2-yl) fluorophosphonate
• IUPAC Traditional name: isoflurophate
• Synonyms: Phosphoric acid diisopropyl ester fluoride; DFP; 二异丙基氟磷酸酯; Diisopropyl phosphorofluoridate; DIFP; 氟代磷酸二异丙酯

DATABASE IDS

• CAS Number: 55-91-4
• MDL Number: MFCD00008873
• PubChem SID: 24863641
• EC Number: 200-247-6
• Beilstein Number: 1723307

PROPERTIES

• Linear Formula: [(CH3)2CHO]2POF
• Purity: ≥97.0% (GC)
• Gene Information: human ... PTGS1(5742), PTGS2(5743)
• Boiling Point: 62 °C/9 mmHg(lit.)
• Density: 1.06 g/mL at 25 °C(lit.)
• Melting Point: -82 °C(lit.)
• Refractive Index: n20/D 1.385(lit.)
• Vapor Pressure: 0.58 mmHg ( 20 °C)
• GHS Signal Word: Danger
• GHS Hazard statements: H300 +H310 + H330
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 3382 6.1/PG 1
• Risk Statements: 26/27/28
• RTECS: TE5075000
• Safety Statements: 36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 3382
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Analysis Note
Typically used at a concentration of 0.10 mM. A safer alternative inhibitor for serine protease is phenylmethylsulfonyl fluoride (PMSF).
Other Notes
Potent inhibitor of chymotrypsin and other enzymes (e.g. serine hydrolases)1; Inhibition of carboxypeptidase but not DAP I2
Biochem/physiol Actions
Potent inhibitor of serine proteases such as trypsin and chymotrypsin, and of acetylcholinesterase; also inhibits cathepsin G, cholinesterase, coagulation factor Xa, leucocyte elastase, pancreatic elastase, tissue kallikrein, plasmin, subtilisin, and thrombin. Inhibition of acetylcholinesterase makes this compound especially toxic. Inhibits apoptosis induced by ricin and bacterial toxins.

Description (简体中文)

Analysis Note
使用浓度通常为 0.10mM。苯甲基磺酰氟 (PMSF) 是一种更安全的丝氨酸蛋白酶替代抑制剂。
Other Notes
Potent inhibitor of chymotrypsin and other enzymes (e.g. serine hydrolases)1; Inhibition of carboxypeptidase but not DAP I2
Biochem/physiol Actions
丝氨酸蛋白酶（如胰蛋白酶和胰凝乳蛋白酶）和乙酰胆碱酯酶的强效抑制剂；还抑制组织蛋白酶 G、胆碱脂酶、凝血因子 Xa、白细胞弹性蛋白酶、胰弹性蛋白酶、组织激肽释放酶、血纤维蛋白熔酶、枯草杆菌蛋白酶以及凝血酶。乙酰胆碱酯酶的抑制作用使该化合物具有特别强的毒性。抑制由篦麻毒素和细菌毒素诱导的细胞凋亡。