Doxorubicin hydrochloride

• Catalog No.: 44583
• CAS Number: 25316-40-9
• M. F.: C27H30ClNO11
• M. W.: 579.9802
• Purity: 98.0-102.0% (HPLC)

SYNONYMS

• Title: 阿霉素 盐酸盐
• IUPAC name: (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione hydrochloride
• IUPAC Traditional name: doxorubicin hydrochloride
• Synonyms: 羟基柔红霉素 盐酸盐; DOX; 多柔比星® 盐酸盐; Hydroxydaunorubicin hydrochloride

DATABASE IDS

• Beilstein Number: 4229251
• CAS Number: 25316-40-9
• EC Number: 246-818-3
• MDL Number: MFCD00077757
• PubChem SID: 24868204

PROPERTIES

• Empirical Formula (Hill Notation): C27H29NO11 · HCl
• Purity: 98.0-102.0% (HPLC)
• Suitability: suitable for fluorescence
• Fluorescence: λex 470 nm; λem 585 nm in ethanol
• Melting Point: 216 °C (dec.)(lit.)
• Solubility: H2O: soluble50 mg/mL, clear, orange to red
• Solubility: DMSO: soluble
• Solubility: THF: soluble
• Solubility: ethanol: soluble
• Solubility: methanol: soluble
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H315-H319-H350
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P305 + P351 + P338-P308 + P313
• Risk Statements: 45-22-36/38
• RTECS: QI9295900
• Safety Statements: 53-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Frequently Asked Questions
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Application
Do you have application information on this product that you would like to share?
Doxorubicin is used as an antitumour antibiotic, to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells 2,3.
Used to inhibit macromolecular biosynthsis.
Biochem/physiol Actions
Antitumour antibiotic. Effect of adriamycin® on heart mitochondrial DNA;4 Properties.5,6
Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.
Doxorubicin intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent 1.
法律信息
Adriamycin 注册商标 RDF Pharmacia & Upjohn S.P.A.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Description (English)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Do you have application information on this product that you would like to share?
Doxorubicin is used as an antitumour antibiotic, to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells 2,3.
Used to inhibit macromolecular biosynthsis.
Biochem/physiol Actions
Antitumour antibiotic. Effect of adriamycin® on heart mitochondrial DNA;4 Properties.5,6
Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.
Doxorubicin intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent 1.
Legal Information
Adriamycin is a registered trademark of RDF Pharmacia & Upjohn S.P.A.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information