Chlortetracycline hydrochloride

• Catalog No.: 26430
• CAS Number: 64-72-2
• M. F.: C22H24Cl2N2O8
• M. W.: 515.34056
• Purity: ≥97.0% (AT)

SYNONYMS

• Title: 氯四环素 盐酸盐
• IUPAC name: (4S,4aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
• IUPAC Traditional name: aureomycin hydrochloride
• Synonyms: 7-Chlorotetracycline hydrochloride; 金霉素 盐酸盐

DATABASE IDS

• MDL Number: MFCD00082440
• Beilstein Number: 3858364
• CAS Number: 64-72-2
• EC Number: 200-591-7
• PubChem SID: 24856004

PROPERTIES

• Biological Source: from Streptomyces aureofaciens
• Empirical Formula (Hill Notation): C22H23ClN2O8 · HCl
• Impurities: ≤3% water
• Product Line: BioReagent
• Purity: ≥97.0% (AT)
• Suitability: suitable for fluorescence
• Fluorescence: λex 392 nm; λem 536 nm in 0.1 M Tris pH 8.0, 10 mM Ca2+
• Melting Point: 210-215 °C (dec.)(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: QI7800000
• Safety Statements: 26
• Storage Temperature: -20°C
• German water hazard class: 2

DETAILS

Description (English)

Application
Cell-permeable fluorescent probe for Ca2+ for measuring calcium flux in endoplasmic reticulum and other intracellular stores in situ.
Biochem/physiol Actions
Chlortetracycline is an antibiotic produced by some strains of Streptomyces aureofaciens.Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit. Antimicrobial spectrum: Gram-positive. Less active against Gram-negative bacteria than tetracycline.Mode of Resistance: Loss of cell wall permeability.
Quality
Recommended for fluorescent studies of calcium signaling in cells or tissues.

Description (简体中文)

Application
Cell-permeable fluorescent probe for Ca2+ for measuring calcium flux in endoplasmic reticulum and other intracellular stores in situ.
Biochem/physiol Actions
Chlortetracycline is an antibiotic produced by some strains of Streptomyces aureofaciens.Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit. Antimicrobial spectrum: Gram-positive. Less active against Gram-negative bacteria than tetracycline.Mode of Resistance: Loss of cell wall permeability.
Quality
Recommended for fluorescent studies of calcium signaling in cells or tissues.