trans-4-Hydroxy-L-proline

• Catalog No.: 56250
• CAS Number: 51-35-4
• M. F.: C5H9NO3
• M. W.: 131.12986
• Purity: ≥99.0% (NT)

SYNONYMS

• Title: L-羟基脯氨酸
• IUPAC name: (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid
• IUPAC Traditional name: hypro
• Synonyms: (2S,4R)-4-羟基吡咯烷-2-羧酸; Hyp; (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid

DATABASE IDS

• CAS Number: 51-35-4
• EC Number: 200-091-9
• PubChem SID: 24880041
• Beilstein Number: 81441
• MDL Number: MFCD00064320

PROPERTIES

• Antion Traces: chloride (Cl-): ≤100 mg/kg
• Antion Traces: sulfate (SO42-): ≤100 mg/kg
• Cation Traces: Ca: ≤10 mg/kg
• Cation Traces: Cd: ≤5 mg/kg
• Cation Traces: Co: ≤5 mg/kg
• Cation Traces: Cr: ≤5 mg/kg
• Cation Traces: Cu: ≤5 mg/kg
• Cation Traces: Fe: ≤5 mg/kg
• Cation Traces: K: ≤50 mg/kg
• Cation Traces: Mg: ≤5 mg/kg
• Cation Traces: Mn: ≤5 mg/kg
• Cation Traces: NH4+: ≤100 mg/kg
• Cation Traces: Na: ≤50 mg/kg
• Cation Traces: Ni: ≤5 mg/kg
• Cation Traces: Pb: ≤5 mg/kg
• Cation Traces: Zn: ≤5 mg/kg
• Empirical Formula (Hill Notation): C5H9NO3
• Ignition Residue: ≤0.1% (as SO4)
• Impurities: ≤0.3% foreign amino acids
• Loss on Drying: ≤0.1% loss on drying, 110 °C
• Product Line: BioXtra
• Purity: ≥99.0% (NT)
• Melting Point: 273 °C (dec.)(lit.)
• Optical Rotation: [α]20/D -76.0±1.5°, c = 5% in H2O
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Natural constituent of animal structural proteins such as collagen and elastin.
Enzymes and intermediates of hydroxyproline degradation1
Biochem/physiol Actions
Trans-4-Hydroxy-L-proline is used as a starting material in the synthesis of (-)-secrinine; the synthesis of prolinol-based nucleotide analogues with N-phosphonomethyl moiety attached to the nitrogen atom of prolinol ring and in asymmetric synthesis of the ABC-ring system of the antitumor antibiotic MPC1001.
Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.

Description (简体中文)

Other Notes
动物结构蛋白（如胶原和弹性蛋白）的天然成分。
Enzymes and intermediates of hydroxyproline degradation1
Biochem/physiol Actions
Trans-4-Hydroxy-L-proline is used as a starting material in the synthesis of (-)-secrinine; the synthesis of prolinol-based nucleotide analogues with N-phosphonomethyl moiety attached to the nitrogen atom of prolinol ring and in asymmetric synthesis of the ABC-ring system of the antitumor antibiotic MPC1001.
Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.