Cloxacillin sodium salt

• Catalog No.: 27555
• CAS Number: 642-78-4
• M. F.: C19H17ClN3NaO5S
• M. W.: 457.86315
• Purity: ≥97.0% (HPLC)

SYNONYMS

• IUPAC name: sodium (2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• IUPAC Traditional name: sodium cloxacillin(1-)

DATABASE IDS

• CAS Number: 642-78-4
• EC Number: 211-390-9
• PubChem SID: 24856654
• MDL Number: MFCD00063568
• Beilstein Number: 4103180

PROPERTIES

• Empirical Formula (Hill Notation): C19H17ClN3NaO5S
• Impurities: ≤5% water
• Purity: ≥97.0% (HPLC)
• Solubility: H2O: soluble50 mg/mL, clear, colorless
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: XH8750000
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Cloxacillin interferes with the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins. This inhibits the necessary cross-linking and leads to autolysis of the bacteria by autolysins.
Application
Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce β-lactamase. It is used to study the role of pH in antibiotic effectiveness1 and how oxgall, acid, and hydrogen peroxide stress effects the susceptibility of Bifidobacteria2.

Description (简体中文)

Biochem/physiol Actions
Cloxacillin interferes with the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins. This inhibits the necessary cross-linking and leads to autolysis of the bacteria by autolysins.
Application
Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce β-lactamase. It is used to study the role of pH in antibiotic effectiveness1 and how oxgall, acid, and hydrogen peroxide stress effects the susceptibility of Bifidobacteria2.