Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride

• Catalog No.: 90182
• CAS Number: 4272-74-6
• M. F.: C14H22Cl2N2O3S
• M. W.: 369.30708
• Purity: ≥99.0% (AT)

SYNONYMS

• IUPAC name: (3S)-7-amino-1-chloro-S-(4-methylphenyl)-2-oxoheptane-3-sulfonamido hydrochloride
• IUPAC Traditional name: C14H21ClN2O3S hydrochloride
• Synonyms: (3S)-7-Amino-1-chloro-3-tosylamino-2-heptanone hydrochloride; (3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride; TLCK; Tosyl-L-lysyl-chloromethane hydrochloride

DATABASE IDS

• PubChem SID: 24889312
• MDL Number: MFCD00065395
• CAS Number: 4272-74-6
• EC Number: 224-266-4
• Beilstein Number: 7106867

PROPERTIES

• Empirical Formula (Hill Notation): C14H21ClN2O3S · HCl
• Purity: ≥99.0% (AT)
• Optical Rotation: [α]20/D -7.8±0.5°, c = 2% in H2O
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: XT5160000
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Other Notes
An alkylating reagent that may react with histidine or cysteine residues at the active site of enzymes. Inactivates serine proteases such as trypsin 1,2,3 and clostripain 4. Chymotrypsin is not affected. To prevent proteolytic degradation, a combination of TLCK and TPCK can be used throughout the isolation of proteins, as in the isolation of histones.5

Description (English)

Other Notes
An alkylating reagent that may react with histidine or cysteine residues at the active site of enzymes. Inactivates serine proteases such as trypsin 1,2,3 and clostripain 4. Chymotrypsin is not affected. To prevent proteolytic degradation, a combination of TLCK and TPCK can be used throughout the isolation of proteins, as in the isolation of histones.5