1α,25-Dihydroxyvitamin D3

• Catalog No.: 17936
• CAS Number: 32222-06-3
• M. F.: C27H44O3
• M. W.: 416.63646
• Purity: ≥97.0% (HPLC)

SYNONYMS

• IUPAC name: (1R,3S)-5-{2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
• IUPAC Traditional name: calcitriol oral solution
• Synonyms: Calcitriol; 1α,25-Dihydroxycholecalciferol

DATABASE IDS

• CAS Number: 32222-06-3
• EC Number: 250-963-8
• MDL Number: MFCD00867079
• PubChem SID: 24850808
• Beilstein Number: 7559394

PROPERTIES

• Empirical Formula (Hill Notation): C27H44O3
• Purity: ≥97.0% (HPLC)
• Gene Information: human ... VDR(7421)
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H330-H361
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 2811 6.1/PG 1
• Risk Statements: 63-26/27/28
• RTECS: FZ4645000
• Safety Statements: 36/37/39-45
• Storage Temperature: -70°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Description (简体中文)

Biochem/physiol Actions
Biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.