Bafilomycin B1 from Streptomyces sp.

• Catalog No.: 11707
• CAS Number: 88899-56-3
• M. F.: C44H65NO13
• M. W.: 815.9858
• Purity: ≥80% (HPLC)

SYNONYMS

• IUPAC name: (2R,4R,5S,6R)-2-hydroxy-2-[(2S,3R,4S)-3-hydroxy-4-[(2R,3S,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-(propan-2-yl)oxan-4-yl 3-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)carbamoyl]prop-2-enoate
• IUPAC Traditional name: (2R,4R,5S,6R)-2-hydroxy-2-[(2S,3R,4S)-3-hydroxy-4-[(2R,3S,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-6-isopropyl-5-methyloxan-4-yl 3-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)carbamoyl]prop-2-enoate

DATABASE IDS

• Beilstein Number: 4640118
• CAS Number: 88899-56-3

PROPERTIES

• Empirical Formula (Hill Notation): C44H65NO13
• Purity: ≥80% (HPLC)
• Shipped in: wet ice
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H330
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 3462 6.1/PG 1
• Risk Statements: 26/27/28
• RTECS: NG8841000
• Safety Statements: 36/37/39-45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Warning
Fatal if swallowed.Bafilomycin B1 is fatal if it is inhaled, swallowed, or if it comes in contact with skin.
Application
Bafilomycin B1 is a toxic macrolide antibiotic used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis 1,2.
Biochem/physiol Actions
Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase) and is used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis.
Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase). Bafilomycin B1′s activity results from the presence of a large macrocyclic lactone ring to which deoxy sugars may attach.

Description (简体中文)

Warning
Fatal if swallowed.Bafilomycin B1 is fatal if it is inhaled, swallowed, or if it comes in contact with skin.
Application
Bafilomycin B1 is a toxic macrolide antibiotic used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis 1,2.
Biochem/physiol Actions
Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase) and is used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis.
Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase). Bafilomycin B1′s activity results from the presence of a large macrocyclic lactone ring to which deoxy sugars may attach.