Antipain

• Catalog No.: 10791
• CAS Number: 37691-11-5
• M. F.: C27H44N10O6
• M. W.: 604.70166

SYNONYMS

• IUPAC name: (2S)-2-({[(1S)-4-carbamimidamido-1-{[(1S)-1-[(5-carbamimidamido-1-oxopentan-2-yl)carbamoyl]-2-methylpropyl]carbamoyl}butyl]carbamoyl}amino)-3-phenylpropanoic acid
• IUPAC Traditional name: (2S)-2-({[(1S)-4-carbamimidamido-1-{[(1S)-1-[(5-carbamimidamido-1-oxopentan-2-yl)carbamoyl]-2-methylpropyl]carbamoyl}butyl]carbamoyl}amino)-3-phenylpropanoic acid
• Synonyms: [(S)-1-Carboxy-2-phenylethyl]carbamoyl-L-arginyl-L-valyl-argininal

DATABASE IDS

• EC Number: 253-631-0
• Beilstein Number: 6837629
• MDL Number: MFCD00135959
• CAS Number: 37691-11-5
• PubChem SID: 24846788

PROPERTIES

• Empirical Formula (Hill Notation): C27H44N10O6
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: YV9350700
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Inhibits serine/cysteine proteases and some trypsin-like proteases. Compare activity to that of leupeptin. Used to evaluate the role of proteases in cell transformations. Used to help identify new proteases.
Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.1
Other Notes
Protease inhibitor2
Unit Definition
1 U corresponds to the amount of inhibitor which reduces the trypsin activity by 1 BAEE-U. (1 BAEE-U is the amount of enzyme which increases the absorbance at 253 nm by 0.001 per minute at pH 7.6 and 25°C; BAEE, Fluka No. 12880, as substrate)

Description (简体中文)

Biochem/physiol Actions
Inhibits serine/cysteine proteases and some trypsin-like proteases. Compare activity to that of leupeptin. Used to evaluate the role of proteases in cell transformations. Used to help identify new proteases.
Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.1
Other Notes
Protease inhibitor2
Unit Definition
1 U corresponds to the amount of inhibitor which reduces the trypsin activity by 1 BAEE-U. (1 BAEE-U is the amount of enzyme which increases the absorbance at 253 nm by 0.001 per minute at pH 7.6 and 25°C; BAEE, Fluka No. 12880, as substrate)