Gentamicin sulfate from Micromonospora purpurea

• Catalog No.: 48760
• CAS Number: 1405-41-0
• M. F.: C60H125N15O25S
• M. W.: 1488.785

SYNONYMS

• Title: 庆大霉素 硫酸酯 来源于紫红小单孢菌
• IUPAC name: (2R,3R,4R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol; (2R,3R,4R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-[(1R)-1-(methylamino)ethyl]oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol; (2R,3R,4R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-[(1R)-1-aminoethyl]oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol; sulfuric acid
• IUPAC Traditional name: (2R,3R,4R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol; (2R,3R,4R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-[(1R)-1-(methylamino)ethyl]oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol; (2R,3R,4R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-[(1R)-1-aminoethyl]oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol; sulfuric acid

DATABASE IDS

• MDL Number: MFCD00270181
• EC Number: 215-778-9
• CAS Number: 1405-41-0

PROPERTIES

• Impurities: ≤10% water
• Linear Formula: C19-21H39-43N5O7 · 2.5H2SO4
• Mol. Weight: Mr 694-723
• Optical Rotation: [α]20/D +110±8°, c = 1% in H2O
• pH: 4.0-5.5 (0.1 g/mL in H2O)
• Solubility: H2O: soluble0.1 g/mL, clear, very faintly yellow
• GHS Signal Word: Danger
• GHS Hazard statements: H317-H334
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P342 + P311
• Risk Statements: 42/43
• RTECS: LY2625000
• Safety Statements: 22-36/37-45
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Application
Used as a selection agent (gentamicin-resistance gene) in molecular biology applications.
Biochem/physiol Actions
Mode of Action: Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasma.
Unit Definition
1 U corresponds to 1 μg of the USP gentamicin sulfate reference standard

Description (简体中文)

Application
Used as a selection agent (gentamicin-resistance gene) in molecular biology applications.
Biochem/physiol Actions
作用方式：通过结合到 50S 核糖体亚基的 L6 蛋白上抑制蛋白质的合成。 抗菌谱：革兰氏阴性菌、革兰氏阳性菌和支原体。
Unit Definition
1U 对应于 1μg USP 级硫酸庆大霉素标准品