Apigenin

• Catalog No.: 10798
• CAS Number: 520-36-5
• M. F.: C15H10O5
• M. W.: 270.2369
• Purity: ≥95.0% (HPLC)

SYNONYMS

• IUPAC name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
• IUPAC Traditional name: chamomile
• Synonyms: 4′,5,7-Trihydroxyflavone

DATABASE IDS

• EC Number: 208-292-3
• CAS Number: 520-36-5
• Beilstein Number: 262620
• PubChem SID: 24846790
• MDL Number: MFCD00006831

PROPERTIES

• Empirical Formula (Hill Notation): C15H10O5
• Impurities: ~2% water
• Purity: ≥95.0% (HPLC)
• Gene Information: human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931)mouse ... Hexa(15211)rat ... Adora1(29290), Adora2a(25369), Il4(287287), Tnf(24835)
• Melting Point: >300 °C(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: LK9276000
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Inhibitor of human estrogen synthetase2
Biochem/physiol Actions
A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53.Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C1 and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

Description (简体中文)

Other Notes
Inhibitor of human estrogen synthetase2
Biochem/physiol Actions
A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53.Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C1 and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.