Tetracycline

• Catalog No.: 87128
• CAS Number: 60-54-8
• M. F.: C22H24N2O8
• M. W.: 444.43456
• Purity: ≥98.0% (NT)

SYNONYMS

• Title: 四环素
• IUPAC name: (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
• IUPAC Traditional name: tetracycline

DATABASE IDS

• MDL Number: MFCD00151232
• PubChem SID: 24888860
• EC Number: 200-481-9
• CAS Number: 60-54-8
• Beilstein Number: 2230417

PROPERTIES

• Empirical Formula (Hill Notation): C22H24N2O8 · xH2O
• Impurities: 4-11% water
• Purity: ≥98.0% (NT)
• Suitability: suitable for 1694 per US EPA
• Gene Information: human ... CYP1A2(1544), TERT(7015)
• Melting Point: 172-174 °C (dec.)
• Optical Rotation: [α]20/D -230±5°, c = 1% in methanol
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• RTECS: QI8750000
• Safety Statements: 22-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Review4; Inhibitor of protein synthesis, binds to the 30S subunit and inhibits binding of aminoacyl-tRNAs.
Application
Tetracycline is an inhibitor of protein synthesis and is used in tetracycline controlled gene expression systems (gene switches) such a the tet-on and tet-off systems 1. It is also used to select tetracyline resistant colonies in cell culture 2.
Biochem/physiol Actions
Tetracycline binds to the 30S subunit of the ribosome at the A-site. During protein biosynthesis, the new t-RNA with the amino acid attempts to bind to the A-site of the ribosome. However, since the A-site is blocked by the tetracycline, the aminoacyl-tRNA cannot bind to it. Without the attachment of the tRNA, protein biosynthesis cannot occur. Protein biosynthesis is inhibited and cell death occurs 3.

Description (简体中文)

Other Notes
Review4; Inhibitor of protein synthesis, binds to the 30S subunit and inhibits binding of aminoacyl-tRNAs.
Application
Tetracycline is an inhibitor of protein synthesis and is used in tetracycline controlled gene expression systems (gene switches) such a the tet-on and tet-off systems 1. It is also used to select tetracyline resistant colonies in cell culture 2.
Biochem/physiol Actions
Tetracycline binds to the 30S subunit of the ribosome at the A-site. During protein biosynthesis, the new t-RNA with the amino acid attempts to bind to the A-site of the ribosome. However, since the A-site is blocked by the tetracycline, the aminoacyl-tRNA cannot bind to it. Without the attachment of the tRNA, protein biosynthesis cannot occur. Protein biosynthesis is inhibited and cell death occurs 3.