Daunorubicin hydrochloride

• Catalog No.: 30450
• CAS Number: 23541-50-6
• M. F.: C27H30ClNO10
• M. W.: 563.9808
• Purity: ≥90% (HPLC)

SYNONYMS

• Title: 柔红霉素 盐酸盐
• IUPAC name: (8S,10S)-8-acetyl-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione hydrochloride
• IUPAC Traditional name: daunorubicin hydrochloride
• Synonyms: Daunomycin hydrochloride; 道诺霉素 盐酸盐

DATABASE IDS

• PubChem SID: 24858374
• MDL Number: MFCD04974507
• CAS Number: 23541-50-6
• EC Number: 245-723-4
• Beilstein Number: 4229221

PROPERTIES

• Empirical Formula (Hill Notation): C27H29NO10 · HCl
• Purity: ≥90% (HPLC)
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H334-H351
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P281-P301 + P310-P342 + P311
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 22-40-42/43
• RTECS: HB7878000
• Safety Statements: 22-36/37-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Daunorubicin inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent. On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.
Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent. Properties
Application
Daunorubicin hydrochloride is used in photostability 1, antileukemic, 2, and drug metabolism studies 3.

Description (简体中文)

Biochem/physiol Actions
Daunorubicin inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent. On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.
强效抗癌剂，已证明是 DNA 和 RNA 合成的强抑制剂。性质
Application
Daunorubicin hydrochloride is used in photostability 1, antileukemic, 2, and drug metabolism studies 3.