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Trimethoprim

Catalog No. 92131 Name Sigma Aldrich
CAS Number 738-70-5 Website http://www.sigmaaldrich.com
M. F. C14H18N4O3 Telephone 1-800-521-8956
M. W. 290.31772 Fax
Purity ≥99.0% (HPLC) Email
Storage Chembase ID: 323

SYNONYMS

Title
甲氧苄啶
IUPAC name
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
IUPAC Traditional name
trimethoprim
Synonyms
2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

DATABASE IDS

MDL Number MFCD00036761
Beilstein Number 625127
EC Number 212-006-2
CAS Number 738-70-5
PubChem SID 24889615

PROPERTIES

Empirical Formula (Hill Notation) C14H18N4O3
Purity ≥99.0% (HPLC)
Quality crystallized
Gene Information human ... DHFRP1(573971), KCNH1(3756)rat ... Dhfr(24312)
Melting Point 199-203 °C
Solubility chloroform/ethanol (1:1): soluble50 mg/mL, clear, colorless
MSDS Link Download
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS UV8225000
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Application
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis 1 and mechanism of resistance studies in Haemophilus influenzae 2.
Biochem/physiol Actions
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Other Notes
Specific inhibitor of formulation. Widely used in studies on dihydrofolate reductase3,4.
Description (简体中文)
Application
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis 1 and mechanism of resistance studies in Haemophilus influenzae 2.
Biochem/physiol Actions
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Other Notes
Specific inhibitor of formulation. Widely used in studies on dihydrofolate reductase3,4.

REFERENCES