Trimethoprim

• Catalog No.: 92131
• CAS Number: 738-70-5
• M. F.: C14H18N4O3
• M. W.: 290.31772
• Purity: ≥99.0% (HPLC)

SYNONYMS

• Title: 甲氧苄啶
• IUPAC name: 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
• IUPAC Traditional name: trimethoprim
• Synonyms: 2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶; 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

DATABASE IDS

• MDL Number: MFCD00036761
• Beilstein Number: 625127
• EC Number: 212-006-2
• CAS Number: 738-70-5
• PubChem SID: 24889615

PROPERTIES

• Empirical Formula (Hill Notation): C14H18N4O3
• Purity: ≥99.0% (HPLC)
• Quality: crystallized
• Gene Information: human ... DHFRP1(573971), KCNH1(3756)rat ... Dhfr(24312)
• Melting Point: 199-203 °C
• Solubility: chloroform/ethanol (1:1): soluble50 mg/mL, clear, colorless
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: UV8225000
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis 1 and mechanism of resistance studies in Haemophilus influenzae 2.
Biochem/physiol Actions
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Other Notes
Specific inhibitor of formulation. Widely used in studies on dihydrofolate reductase3,4.

Description (简体中文)

Application
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis 1 and mechanism of resistance studies in Haemophilus influenzae 2.
Biochem/physiol Actions
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Other Notes
Specific inhibitor of formulation. Widely used in studies on dihydrofolate reductase3,4.