Difloxacin hydrochloride

• Catalog No.: D2819
• CAS Number: 91296-86-5
• M. F.: C21H20ClF2N3O3
• M. W.: 435.8516064
• Purity: ≥98% (HPLC)

SYNONYMS

• Title: 双氟沙星 盐酸盐
• IUPAC name: 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
• IUPAC Traditional name: difloxacin hydrochloride
• Synonyms: 6-氟-1-(4-氟苯基)-7-(4-甲基哌嗪-1-基)-4-氧代喹啉-3-甲酸 盐酸盐; 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid hydrochloride

DATABASE IDS

• MDL Number: MFCD03840489
• CAS Number: 91296-86-5

PROPERTIES

• Empirical Formula (Hill Notation): C21H19F2N3O3 · HCl
• Purity: ≥98% (HPLC)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Difloxacin inhibits bacterial DNA gyrase and the topoisomerase II enzyme, which inhibits DNA replication and transcription
Fluoroquinolone antibacterial compound. Structurally related to norfloxacin.
Pefloxacin is a synthetic fluoroquinolone that functions an antibacterial agent. It is an analog of norfloxacin. Mode of Action: A ds-DNA binding DNA gyrase inhibitor to dysrupt DNA synthesis. Use to study the metabolism of glycosaminoglycans and collagen in organ cultures of articular cartilage. Antimicrobial spectrum: Pefloxacin is highly active against Staphylococcus aureus, E. coli, other enterobacteria, and Pseudomonas aeruginosa.1 Active against gram-positive bacteria and excellent activity against gram-negative bacteria.2
Application
Difloxacin is a fluoroquinolone antibiotic commonly used in veterinary medicine. It is a potential treatment for Chlamydia trachomatis infections1 and chronic Q fever in humans2. It has been used to study how potential supplementation (magnesium) may reduce quinolone-induced damage in the horse and dog models3.

Description (简体中文)

Biochem/physiol Actions
Difloxacin inhibits bacterial DNA gyrase and the topoisomerase II enzyme, which inhibits DNA replication and transcription
Fluoroquinolone antibacterial compound. Structurally related to norfloxacin.
Pefloxacin is a synthetic fluoroquinolone that functions an antibacterial agent. It is an analog of norfloxacin. Mode of Action: A ds-DNA binding DNA gyrase inhibitor to dysrupt DNA synthesis. Use to study the metabolism of glycosaminoglycans and collagen in organ cultures of articular cartilage. Antimicrobial spectrum: Pefloxacin is highly active against Staphylococcus aureus, E. coli, other enterobacteria, and Pseudomonas aeruginosa.1 Active against gram-positive bacteria and excellent activity against gram-negative bacteria.2
Application
Difloxacin is a fluoroquinolone antibiotic commonly used in veterinary medicine. It is a potential treatment for Chlamydia trachomatis infections1 and chronic Q fever in humans2. It has been used to study how potential supplementation (magnesium) may reduce quinolone-induced damage in the horse and dog models3.