Pyr3

• Catalog No.: P0032
• M. F.: C16H11Cl3F3N3O3
• M. W.: 456.6310496
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: ethyl 1-[4-(trichloroprop-2-enamido)phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
• IUPAC Traditional name: ethyl 1-[4-(trichloroprop-2-enamido)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate
• Synonyms: Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

DATABASE IDS

• MDL Number: MFCD00178741

PROPERTIES

• Empirical Formula (Hill Notation): C16H11Cl3F3N3O3
• Purity: ≥98% (HPLC)
• Apperance: off-white powder
• Solubility: DMSO: >20 mg/mL
• RID/ADR: UN 3077 9/PG 3
• Storage Temperature: 2-8°C
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3

DETAILS

Description (English)

Biochem/physiol Actions
Pyr3 is a pyrazole compound that potently and selectively antagonizes TRPC3. Pyr3 inhibits TRPC3 by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy.Members of the canonical transient receptor potential (TRPC) channel family are ion channels which conduct Ca+2 and are activated by membrane receptor-mediated stimulation of phospholipase C (PLC) activity. However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). BTP1 and BTP2 are pyrazoles that block TRPC channels, but they are not specific for TRPC subtypes. This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca+2 oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.
Pyr3 is a selectively inhibitor of TRPC3. It acts by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy.Members of the canonical transient receptor potential (TRPC) channel family are Ca2+ ion channels that are activated by membrane receptor-mediated stimulation of phospholipase C (PLC). However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca2+ oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.

Description (简体中文)

Biochem/physiol Actions
Pyr3 is a pyrazole compound that potently and selectively antagonizes TRPC3. Pyr3 inhibits TRPC3 by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy.Members of the canonical transient receptor potential (TRPC) channel family are ion channels which conduct Ca+2 and are activated by membrane receptor-mediated stimulation of phospholipase C (PLC) activity. However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). BTP1 and BTP2 are pyrazoles that block TRPC channels, but they are not specific for TRPC subtypes. This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca+2 oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.
Pyr3 is a selectively inhibitor of TRPC3. It acts by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy.Members of the canonical transient receptor potential (TRPC) channel family are Ca2+ ion channels that are activated by membrane receptor-mediated stimulation of phospholipase C (PLC). However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca2+ oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.