Ilmofosine

• Catalog No.: I2409
• CAS Number: 83519-04-4
• M. F.: C26H56NO5PS
• M. W.: 525.765301

SYNONYMS

• IUPAC name: 3-(hexadecylsulfanyl)-2-(methoxymethyl)propyl 2-(trimethylazaniumyl)ethyl phosphate
• IUPAC Traditional name: ilmofosine
• Synonyms: BM 41.440; 1-Hexadecylmercapto-2-methoxymethyl-3-propyl phosphoric acid monocholine ester

DATABASE IDS

• CAS Number: 83519-04-4
• MDL Number: MFCD00869023
• PubChem SID: 24724510

PROPERTIES

• Empirical Formula (Hill Notation): C26H56NO5PS
• Apperance: semisolid (waxy)
• Solubility: H2O: soluble10 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 22
• RTECS: JH4758000
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Packaging
Air-sensitive, sealed under nitrogen
Biochem/physiol Actions
Protein Kinase C (PKC) inhibitor; an ether lipid derivative of lysophosphatidylcholine has antineoplastic activity in vitro and in vivo. IC50 = 560 nM. Competitive at the regulatory site of PKC. Ilmofosine is active against a variety of explanted human non-small cell lung, breast, colorectal, ovarian, renal cell cancer, and melanoma tumors in vitro at concentrations of 1-30 μg/mL.

Description (简体中文)

包装
Air-sensitive, sealed under nitrogen
Biochem/physiol Actions
Protein Kinase C (PKC) inhibitor; an ether lipid derivative of lysophosphatidylcholine has antineoplastic activity in vitro and in vivo. IC50 = 560 nM. Competitive at the regulatory site of PKC. Ilmofosine is active against a variety of explanted human non-small cell lung, breast, colorectal, ovarian, renal cell cancer, and melanoma tumors in vitro at concentrations of 1-30 μg/mL.