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Chromeceptin

Catalog No. C0868 Name Sigma Aldrich
CAS Number 331859-86-0 Website http://www.sigmaaldrich.com
M. F. C19H16F3N3O Telephone 1-800-521-8956
M. W. 359.3450496 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 155781

SYNONYMS

IUPAC name
2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile
IUPAC Traditional name
2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile
Synonyms
94G6
2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene

DATABASE IDS

CAS Number 331859-86-0
MDL Number MFCD00815850
PubChem SID 24724431

PROPERTIES

Empirical Formula (Hill Notation) C19H16F3N3O
Purity ≥98% (HPLC)
Apperance yellow to brown solid
Solubility H2O: <2 mg/mL
Solubility DMSO: >20 mg/mL
MSDS Link Download
Storage Temperature -20°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.
Description (简体中文)
Biochem/physiol Actions
Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.

REFERENCES