Chromeceptin

• Catalog No.: C0868
• CAS Number: 331859-86-0
• M. F.: C19H16F3N3O
• M. W.: 359.3450496
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile
• IUPAC Traditional name: 2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile
• Synonyms: 94G6; 2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene

DATABASE IDS

• CAS Number: 331859-86-0
• MDL Number: MFCD00815850
• PubChem SID: 24724431

PROPERTIES

• Empirical Formula (Hill Notation): C19H16F3N3O
• Purity: ≥98% (HPLC)
• Apperance: yellow to brown solid
• Solubility: H2O: <2 mg/mL
• Solubility: DMSO: >20 mg/mL
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.

Description (简体中文)

Biochem/physiol Actions
Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.