A-85783

• Catalog No.: A1471
• CAS Number: 161395-33-1
• M. F.: C29H23FN4O2S
• M. W.: 510.5819232

SYNONYMS

• IUPAC name: 6-(4-fluorophenyl)-N,N-dimethyl-3-[(3R)-3-(pyridin-3-yl)-1H,3H-pyrrolo[1,2-c][1,3]thiazole-7-carbonyl]-1H-indole-1-carboxamide
• IUPAC Traditional name: 6-(4-fluorophenyl)-N,N-dimethyl-3-[(3R)-3-(pyridin-3-yl)-1H,3H-pyrrolo[1,2-c][1,3]thiazole-7-carbonyl]indole-1-carboxamide
• Synonyms: (R)-6-(4-Fluorophenyl)-N,N-dimethyl-3-[3-(3-pyridinyl)-1H,3H-pyrrolo[1,2-c]thiazol-7-yl]carbonyl-1H-indole-1-carboxamide

DATABASE IDS

• CAS Number: 161395-33-1
• MDL Number: MFCD00935061

PROPERTIES

• Empirical Formula (Hill Notation): C29H23FN4O2S
• Melting Point: 185.3-186.5 °C(lit.)
• Solubility: DMSO: soluble13 mg/mL
• Solubility: H2O: insoluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Potent and selective platelet-activating factor (PAF) receptor antagonist.
General description
Shown to be effective both in vivo and in vitro. A-85783 is neutral and lipophilic and has been shown to competitively and reversibly inhibit [3H]PAF binding to rabbit platelet membranes as well as block PAF-induced serotonin release from rabbit platelets.
Legal Information
Sold under license from Abbott Laboratories.

Description (简体中文)

Biochem/physiol Actions
Potent and selective platelet-activating factor (PAF) receptor antagonist.
General description
Shown to be effective both in vivo and in vitro. A-85783 is neutral and lipophilic and has been shown to competitively and reversibly inhibit [3H]PAF binding to rabbit platelet membranes as well as block PAF-induced serotonin release from rabbit platelets.
Legal Information
Sold under license from Abbott Laboratories.