Tyrphostin AG 528

• Catalog No.: T4568
• CAS Number: 133550-49-9
• M. F.: C18H14N2O3
• M. W.: 306.31536
• Purity: ~90%

SYNONYMS

• IUPAC name: 2-(2,3-dihydro-1H-indole-1-carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
• IUPAC Traditional name: 2-(2,3-dihydroindole-1-carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
• Synonyms: N-(3′,4′-Dihydroxybenzylidenecyanoacetyl)indoline; Tyrphostin B66

DATABASE IDS

• PubChem SID: 24278034
• MDL Number: MFCD01076474
• CAS Number: 133550-49-9

PROPERTIES

• Empirical Formula (Hill Notation): C18H14N2O3
• Potency: IC50 (2.1 micromolar, HER1-2 kinase activity)
• Potency: IC50 (4.9 micromolar for EGFK kinase activity)
• Purity: ~90%
• Gene Information: human ... EGFR(1956), ERBB2(2064)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
EGFR protein tyrosine kinase inhibitor.

Description (简体中文)

Biochem/physiol Actions
EGFR protein tyrosine kinase inhibitor.