N-(4-Acetamidophenyl)indomethacinamide

• Catalog No.: A1224
• M. F.: C27H24ClN3O4
• M. W.: 489.95016
• Purity: ≥98%

SYNONYMS

• IUPAC name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-(4-acetamidophenyl)acetamide
• IUPAC Traditional name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-(4-acetamidophenyl)acetamide
• Synonyms: N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide; N-4AcetIA

DATABASE IDS

• MDL Number: MFCD02683236

PROPERTIES

• Empirical Formula (Hill Notation): C27H24N3O4Cl
• Purity: ≥98%
• Shipped in: wet ice
• Absorption Wavelength: λmax 267 nm
• Apperance: crystalline
• Solubility: DMSO: ≥15 mg/mL
• Solubility: DMF: ≥23 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Potent and selective reversible COX-2 inhibitor. N-4-AcetIA inhibits human and ovine COX-2 with IC50 of 0.1 μM and 0.625 μM, respectively. About 400 times less potent as an inhibitor of human COX-1 and 80 times less potent as an inhibitor of ovine COX-1. Shows anti-inflammatory, antiangiogenic, and cancer chemopreventive activity in various experimental models.

Description (简体中文)

Biochem/physiol Actions
Potent and selective reversible COX-2 inhibitor. N-4-AcetIA inhibits human and ovine COX-2 with IC50 of 0.1 μM and 0.625 μM, respectively. About 400 times less potent as an inhibitor of human COX-1 and 80 times less potent as an inhibitor of ovine COX-1. Shows anti-inflammatory, antiangiogenic, and cancer chemopreventive activity in various experimental models.