Alsterpaullone

• Catalog No.: A4847
• CAS Number: 237430-03-4
• M. F.: C16H11N3O3
• M. W.: 293.27684
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 14-nitro-8,18-diazatetracyclo[9.7.0.0^2,^7.0^1^2,^1^7]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one
• IUPAC Traditional name: alsterpaullone
• Synonyms: 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one

DATABASE IDS

• MDL Number: MFCD02683579
• PubChem SID: 24890918
• CAS Number: 237430-03-4

PROPERTIES

• Empirical Formula (Hill Notation): C16H11N3O3
• Purity: ≥98% (HPLC)
• Gene Information: rat ... Gsk3b(84027)
• Apperance: yellow to brown powder
• Solubility: DMSO: ≥10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC50 = 0.035 μM).
Application
Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.

Description (简体中文)

Biochem/physiol Actions
Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC50 = 0.035 μM).
Application
Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.