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Thio-TEPA

Catalog No. T6069 Name Sigma Aldrich
CAS Number 52-24-4 Website http://www.sigmaaldrich.com
M. F. C6H12N3PS Telephone 1-800-521-8956
M. W. 189.218341 Fax
Purity 98% Email
Storage Chembase ID: 4140

SYNONYMS

IUPAC name
tris(aziridin-1-yl)-λ5-phosphanethione
IUPAC Traditional name
thiophosphamide
Synonyms
Thio-Tep
Thiotef
N,N′,N″-Triethylenethiophosphoramide
Thiofozil
Tiofozil
Tio-tef
Tris(aziridinyl)phosphine sulfide
Tiofosyl
Tiofosfamid

DATABASE IDS

MDL Number MFCD00145452
PubChem SID 24900346
CAS Number 52-24-4
EC Number 200-135-7

PROPERTIES

Purity 98%
Empirical Formula (Hill Notation) C6H12N3PS
Apperance solid
GHS Pictograms GHS06
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H300-H350
European Hazard Symbols Highly toxic Highly toxic (T+)
MSDS Link Download
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P264-P301 + P310-P308 + P313
RID/ADR UN 2811 6.1/PG 2
Risk Statements 45-46-28
RTECS SZ2975000
Safety Statements 53-22-26-36/37/39-45
Storage Temperature 2-8°C
Hazard Class 6.1
UN Number 2811
Packing Group 2
German water hazard class 3

DETAILS

Description (English)
Application
Thio-TEPA (N,N’N’-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to haematopoietic progenitor cell transplantation (HPCT)1,2.
Biochem/physiol Actions
The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division1.
Description (简体中文)
Application
Thio-TEPA (N,N’N’-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to haematopoietic progenitor cell transplantation (HPCT)1,2.
Biochem/physiol Actions
The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division1.

REFERENCES