Osteoprotegerin/Fc Chimera from mouse

• Catalog No.: O8137
• M. F.: C18H32O2
• M. W.: 280.44548
• Purity: >95% (SDS-PAGE)

SYNONYMS

• IUPAC name: octadec-7-ynoic acid
• IUPAC Traditional name: 7-octadecynoic acid
• Synonyms: OPG; OCIF

DATABASE IDS

• MDL Number: MFCD01867131
• PubChem SID: 24898055

PROPERTIES

• Impurities: endotoxin, tested
• Mol. Weight: calculated mol wt 70.9 kDa
• Mol. Weight: mol wt 100 kDa by SDS-PAGE (reducing)
• Purity: >95% (SDS-PAGE)
• Recombinant: expressed in NSO cells
• Gene Information: mouse ... Tnfrsf11b(18383)
• Apperance: lyophilized powder
• Storage Temperature: -20°C

DETAILS

Description (English)

Analysis Note
The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL.
General description
Mouse OPG (amino acids 22-401) is fused downstream of the human IL-3Rα signal sequence to the C-terminal histidine-tagged Fc portion of human IgG1.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Biochem/physiol Actions
OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG.

Description (简体中文)

Analysis Note
The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL.
General description
Mouse OPG (amino acids 22-401) is fused downstream of the human IL-3Rα signal sequence to the C-terminal histidine-tagged Fc portion of human IgG1.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Biochem/physiol Actions
OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG.