Cycloheximide solution

• Catalog No.: C4859
• CAS Number: 66-81-9
• M. F.: C15H23NO4
• M. W.: 281.34742

SYNONYMS

• Title: 放线菌酮 溶液
• IUPAC name: 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
• IUPAC Traditional name: kaken
• Synonyms: CHX

DATABASE IDS

• CAS Number: 66-81-9
• PubChem SID: 24892732
• MDL Number: MFCD00082346

PROPERTIES

• Biological Source: microbial
• Concentration: 100 mg/mL in DMSO
• Empirical Formula (Hill Notation): C15H23NO4
• Quality Level: PREMIUM
• Sterility: 0.2 μm filtered
• Gene Information: human ... FKBP1A(2280), PIN1(5300)
• Flash Point: 87 °C
• Flash Point: 188.6 °F
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H315-H319-H341-H360D-H412
• European Hazard Symbols: Highly toxic (T+)
• GHS Precautionary statements: P201-P273-P281-P301 + P310-P305 + P351 + P338-P308 + P313
• RID/ADR: UN 2810 6.1/PG 2
• Risk Statements: 61-28-52/53-68
• Safety Statements: 53-28-36/37-45-61
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2810
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.
Specificity
Tested for cell growth arrest, selection of cycloheximide resistant yeast, apoptosis induction, and facilitation of apoptosis induction by FasL.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Description (简体中文)

Biochem/physiol Actions
Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.
Specificity
Tested for cell growth arrest, selection of cycloheximide resistant yeast, apoptosis induction, and facilitation of apoptosis induction by FasL.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information