CGP-53353

• Catalog No.: C7866
• CAS Number: 145915-60-2
• M. F.: C20H13F2N3O2
• M. W.: 365.3329264

SYNONYMS

• IUPAC name: 5,6-bis[(4-fluorophenyl)amino]-2,3-dihydro-1H-isoindole-1,3-dione
• IUPAC Traditional name: 5,6-bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione
• Synonyms: DAPH 2; 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione

DATABASE IDS

• PubChem SID: 24892990
• CAS Number: 145915-60-2
• MDL Number: MFCD00938569

PROPERTIES

• Empirical Formula (Hill Notation): C20H13F2N3O2
• Gene Information: human ... EGFR(1956)
• Apperance: orange solid
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: insoluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Selective PKCβII inhibitor. IC50 - 410 nM for PKCβII vs 3.8 μM for PKCβI. Inhibits nPKCs and aPKCs only above 22 μM and other kinases such as protein kinase A, casein kinase I and II, c-src kinase, c-lyn kinase, c-fgr kinase, and v-abl kinase at an IC50 of greater than 50 μM.

Description (简体中文)

Biochem/physiol Actions
Selective PKCβII inhibitor. IC50 - 410 nM for PKCβII vs 3.8 μM for PKCβI. Inhibits nPKCs and aPKCs only above 22 μM and other kinases such as protein kinase A, casein kinase I and II, c-src kinase, c-lyn kinase, c-fgr kinase, and v-abl kinase at an IC50 of greater than 50 μM.