Desmosine chloride

• Catalog No.: D9439
• CAS Number: 10019-68-8
• M. F.: C24H40ClN5O8
• M. W.: 562.0561
• Purity: 99.5%±0.2%

SYNONYMS

• IUPAC name: 3,5-bis(3-amino-3-carboxypropyl)-4-(4-amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)pyridin-1-ium chloride
• IUPAC Traditional name: desmosine chloride

DATABASE IDS

• MDL Number: MFCD12910449
• CAS Number: 10019-68-8

PROPERTIES

• Biological Source: from bovine
• Empirical Formula (Hill Notation): C24H40ClN5O8
• Purified By: chromatography (and purified by solvent extraction)
• Purity: 99.5%±0.2%
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Analysis Note
Calibrated by UV and amino acid analysis.
Application
Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema).1 Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).2
Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.
Biochem/physiol Actions
Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.3
Caution
Extremely hygroscopic
General description
Each vial contains 1 μmole of purified desmosine.

Description (简体中文)

Analysis Note
Calibrated by UV and amino acid analysis.
Application
Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema).1 Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).2
Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.
Biochem/physiol Actions
Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.3
Caution
Extremely hygroscopic
General description
Each vial contains 1 μmole of purified desmosine.