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Nodularin_Molecular_structure_CAS_)
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Nodularin

Catalog No. N5148 Name Sigma Aldrich
CAS Number Website http://www.sigmaaldrich.com
M. F. C41H60N8O10 Telephone 1-800-521-8956
M. W. 824.9627 Fax
Purity Email
Storage Chembase ID: 155573

SYNONYMS

Title
节球毒素
IUPAC name
(5R,6S,9S,12S,13S,16R)-9-(3-carbamimidamidopropyl)-2-ethylidene-12-[(5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentaazacyclononadecane-5,16-dicarboxylic acid
IUPAC Traditional name
(5R,6S,9S,12S,13S,16R)-9-(3-carbamimidamidopropyl)-2-ethylidene-12-[(5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentaazacyclononadecane-5,16-dicarboxylic acid
Synonyms
1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide

DATABASE IDS

MDL Number MFCD16659855

PROPERTIES

Empirical Formula (Hill Notation) C41H60N8O10
Solubility methanol: soluble2 mg/mL (Further dilute to 10% (v/v) methanol. Store solutions at -20°C for up to six months.)
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H300 +H310 + H330-H315-H317-H319-H335
European Hazard Symbols Highly toxic Highly toxic (T+)
MSDS Link Download
GHS Precautionary statements P260-P264-P280-P284-P301 + P310-P302 + P350
RID/ADR UN 2811 6.1/PG 2
Risk Statements 26/27/28-36/37/38-43
RTECS GU2294250
Safety Statements 26-36/37/39-45
Storage Temperature 2-8°C
Hazard Class 6.1
UN Number 2811
Packing Group 2
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Potent inhibitor of protein phosphatases types 1 and 2A. Tumor promoter in experimental animal model.1; at higher doses, causes massive liver hemorrhage. Tumor-promoting effect is due to increasing oxidative stress, as evidenced by reduced levels of glutathione and appearance of oxidative damage in DNA bases.2
Description (简体中文)
Biochem/physiol Actions
Potent inhibitor of protein phosphatases types 1 and 2A. Tumor promoter in experimental animal model.1; at higher doses, causes massive liver hemorrhage. Tumor-promoting effect is due to increasing oxidative stress, as evidenced by reduced levels of glutathione and appearance of oxidative damage in DNA bases.2

REFERENCES