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Nodularin
Catalog No.	N5148	Name	Sigma Aldrich
CAS Number		Website	http://www.sigmaaldrich.com
M. F.	C41H60N8O10	Telephone	1-800-521-8956
M. W.	824.9627	Fax
Purity		Email
Storage		Chembase ID: 155573

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SYNONYMS

Title

节球毒素

IUPAC name

(5R,6S,9S,12S,13S,16R)-9-(3-carbamimidamidopropyl)-2-ethylidene-12-[(5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentaazacyclononadecane-5,16-dicarboxylic acid

IUPAC Traditional name

(5R,6S,9S,12S,13S,16R)-9-(3-carbamimidamidopropyl)-2-ethylidene-12-[(5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentaazacyclononadecane-5,16-dicarboxylic acid

Synonyms

1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide

DATABASE IDS

MDL Number

MFCD16659855

PROPERTIES

Empirical Formula (Hill Notation)	C41H60N8O10
Solubility	methanol: soluble2 mg/mL (Further dilute to 10% (v/v) methanol. Store solutions at -20°C for up to six months.)
GHS Pictograms
GHS Signal Word	Danger
GHS Hazard statements	H300 +H310 + H330-H315-H317-H319-H335
European Hazard Symbols	Highly toxic (T+)
MSDS Link	Download
GHS Precautionary statements	P260-P264-P280-P284-P301 + P310-P302 + P350
RID/ADR	UN 2811 6.1/PG 2
Risk Statements	26/27/28-36/37/38-43
RTECS	GU2294250
Safety Statements	26-36/37/39-45
Storage Temperature	2-8°C
Hazard Class	6.1
UN Number	2811
Packing Group	2
German water hazard class	3

DETAILS

Description (English)

Biochem/physiol Actions
Potent inhibitor of protein phosphatases types 1 and 2A. Tumor promoter in experimental animal model.1; at higher doses, causes massive liver hemorrhage. Tumor-promoting effect is due to increasing oxidative stress, as evidenced by reduced levels of glutathione and appearance of oxidative damage in DNA bases.2

Description (简体中文)