Ristomycin monosulfate

• Catalog No.: R7752
• CAS Number: 11140-99-1
• M. F.: C95H110N8O44
• M. W.: 2067.9171
• Purity: ≥90% ristocetin A basis (balance primarily Ristocetin B)

SYNONYMS

• IUPAC name: methyl (1S,2R,18R,19R,22R,34S,37R)-22-amino-2-{[(2R,4R,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-64-{[(2S,3R,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3S,4R,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}oxan-2-yl]oxy}-4,5-dihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-18,26,31,44,49-pentahydroxy-30-methyl-21,35,38,54,56,59-hexaoxo-47-{[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.2^3,^6.2^1^4,^1^7.2^1^9,^3^4.1^8,^1^2.1^2^3,^2^7.1^2^9,^3^3.1^4^1,^4^5.0^1^0,^3^7.0^4^6,^5^1]hexahexaconta-3,5,8(64),9,11,14,16,23,25,27(61),29(60),30,32,41,43,45(57),46,48,50,62,65-henicosaene-52-carboxylate
• IUPAC Traditional name: methyl (1S,2R,18R,19R,22R,34S,37R)-22-amino-2-{[(2R,4R,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-64-{[(2S,3R,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3S,4R,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}oxan-2-yl]oxy}-4,5-dihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-18,26,31,44,49-pentahydroxy-30-methyl-21,35,38,54,56,59-hexaoxo-47-{[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.2^3,^6.2^1^4,^1^7.2^1^9,^3^4.1^8,^1^2.1^2^3,^2^7.1^2^9,^3^3.1^4^1,^4^5.0^1^0,^3^7.0^4^6,^5^1]hexahexaconta-3,5,8(64),9,11,14,16,23,25,27(61),29(60),30,32,41,43,45(57),46,48,50,62,65-henicosaene-52-carboxylate
• Synonyms: Ristocetin sulfate salt

DATABASE IDS

• MDL Number: MFCD00076121
• PubChem SID: 24899399
• CAS Number: 11140-99-1

PROPERTIES

• Empirical Formula (Hill Notation): C95H110N8O44 · H2SO4
• Purity: ≥90% ristocetin A basis (balance primarily Ristocetin B)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: VJ8650000
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Ristocetin activates platelets. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia. Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes suporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals.
Other Notes
Glycopeptide antibiotic complex

Description (简体中文)

Biochem/physiol Actions
Ristocetin activates platelets. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia. Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes suporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals.
Other Notes
Glycopeptide antibiotic complex