Cimetidine

• Catalog No.: C4522
• CAS Number: 51481-61-9
• M. F.: C10H16N6S
• M. W.: 252.33924

SYNONYMS

• IUPAC name: 3-cyano-1-methyl-2-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine
• IUPAC Traditional name: 3-cyano-1-methyl-2-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine
• Synonyms: SKF-92334

DATABASE IDS

• EC Number: 257-232-2
• MDL Number: MFCD00133296
• CAS Number: 51481-61-9
• PubChem SID: 24277766

PROPERTIES

• Empirical Formula (Hill Notation): C10H16N6S
• Suitability: suitable for 1694 per US EPA
• Gene Information: human ... ABCB1(5243), CYP1A2(1544), CYP3A4(1576), HRH2(3274), SLC9A2(6549), SLC9A5(6553)mouse ... Abcb1a(18671), Abcb1b(18669)rat ... Slc9a1(24782), Slc9a3(24784), Slc9a5(192215)
• GHS Signal Word: Danger
• GHS Hazard statements: H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 60
• RTECS: MF0035500
• Safety Statements: 26-36/37/39-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
H2 histamine receptor antagonist; I1 imidazoline receptor agonist; anti-ulcer agent. Blocks cancer metastasis by inhibiting the expression of E-selectin on the surface of endothelial cells, thus blocking tumor cell adhesion.

Description (简体中文)

Biochem/physiol Actions
H2 histamine receptor antagonist; I1 imidazoline receptor agonist; anti-ulcer agent. Blocks cancer metastasis by inhibiting the expression of E-selectin on the surface of endothelial cells, thus blocking tumor cell adhesion.