A1120

• Catalog No.: A3111
• M. F.: C20H19F3N2O3
• M. W.: 392.3716696
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 2-({4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl}amino)benzoic acid
• IUPAC Traditional name: 2-{4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonylamino}benzoic acid
• Synonyms: 2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

DATABASE IDS

• MDL Number: MFCD12912393

PROPERTIES

• Empirical Formula (Hill Notation): C20H19F3N2O3
• Purity: ≥98% (HPLC)
• Apperance: off-white powder
• Solubility: DMSO: ≥10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H317-H319-H400
• European Hazard Symbols: Harmful (Xn)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P280-P305 + P351 + P338
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 22-36-43-50/53
• Safety Statements: 26-36/37-60-61
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4). RBP4 transports retinol from the liver to extrahepatic tissues and RBP4 lowering is reported to improve insulin sensitivity in mice. A1120 is a high affinity non-retinoid ligand for RBP4 which disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). It binds to the same site as retinol and induces changes in the orientation (compared to the retinol bound form) of loops at the RBP4-TTR interaction interface.A1120 lowers RBP4 and retinol levels in a dose-dependent manner, to a similar extent as seen with fenretinide. However, unlike fenretinide (Sigma# H7779), A1120 does not have beneficial effects on insulin resistance.

Description (简体中文)

Biochem/physiol Actions
A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4). RBP4 transports retinol from the liver to extrahepatic tissues and RBP4 lowering is reported to improve insulin sensitivity in mice. A1120 is a high affinity non-retinoid ligand for RBP4 which disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). It binds to the same site as retinol and induces changes in the orientation (compared to the retinol bound form) of loops at the RBP4-TTR interaction interface.A1120 lowers RBP4 and retinol levels in a dose-dependent manner, to a similar extent as seen with fenretinide. However, unlike fenretinide (Sigma# H7779), A1120 does not have beneficial effects on insulin resistance.