Naltriben methanesulfonate hydrate

• Catalog No.: N156
• M. F.: C27H31NO8S
• M. W.: 529.60194
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (1S,2S,13R,21R)-22-(cyclopropylmethyl)-11,14-dioxa-22-azaheptacyclo[13.9.1.0^1,^1^3.0^2,^2^1.0^4,^1^2.0^5,^1^0.0^1^9,^2^5]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol methanesulfonic acid hydrate
• IUPAC Traditional name: methanesulfonic acid naltriben hydrate
• Synonyms: NTB hydrate

DATABASE IDS

• MDL Number: MFCD11046015
• PubChem SID: 24278045

PROPERTIES

• Empirical Formula (Hill Notation): C26H25NO4 · CH4O3S · xH2O
• Purity: ≥98% (HPLC)
• Apperance: off-white solid
• Solubility: DMSO: soluble14 mg/mL at ~60 °C
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: PB9175000
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Naltriben methanesulfonate is a highly selective δ2 opioid receptor antagonist. The relative ability of the delta antagonists benzylidenenaltrexone and naltriben to inhibit DPDPE-stimulated [35S]GTPgammaS binding suggests that the opioid receptor is of the delta-2 subtype. Ligand binding assays demonstrates biphasic binding of the antagonist to the single receptor type. [35S]GTPgammaS binding is also stimulated by [D-Ser2,Leu5,Thr6]enkepha

Description (简体中文)

Biochem/physiol Actions
Naltriben methanesulfonate is a highly selective δ2 opioid receptor antagonist. The relative ability of the delta antagonists benzylidenenaltrexone and naltriben to inhibit DPDPE-stimulated [35S]GTPgammaS binding suggests that the opioid receptor is of the delta-2 subtype. Ligand binding assays demonstrates biphasic binding of the antagonist to the single receptor type. [35S]GTPgammaS binding is also stimulated by [D-Ser2,Leu5,Thr6]enkepha