5α-Pregnan-3α-ol-11,20-dione

• Catalog No.: P5052
• M. F.: C21H32O3
• M. W.: 332.47698
• Purity: ≥98% (TLC)

SYNONYMS

• IUPAC name: (1S,2S,5R,7S,10S,11S,14S,15S)-14-acetyl-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecan-17-one
• IUPAC Traditional name: alfaxalone
• Synonyms: 3-Hydroxy-5α-pregnane-11,20-dione; Alfaxalone

DATABASE IDS

• MDL Number: MFCD00083468
• PubChem SID: 24278637

PROPERTIES

• Purity: ≥98% (TLC)
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRG2(2566)
• Apperance: white powder
• Solubility: chloroform: ≥5 mg/mL, clear, colorless
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 22
• RTECS: TU4157800
• Safety Statements: 22-36
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Synthetic steroid compound alphaxalone (AFX) - 5α-Pregnan-3α-ol-11,20-dione- is a neurosteroid that directly activates and potentiates GABAA receptor-activated membrane current (IGABA). It acts as a positive allosteric modulator of the GABAA receptor; anesthetic. The alpha subunit subtype of GABAA determines the efficacy, but not the potency, of AFX neuroactive steroid to potentiate IGABA.

Description (简体中文)

Biochem/physiol Actions
Synthetic steroid compound alphaxalone (AFX) - 5α-Pregnan-3α-ol-11,20-dione- is a neurosteroid that directly activates and potentiates GABAA receptor-activated membrane current (IGABA). It acts as a positive allosteric modulator of the GABAA receptor; anesthetic. The alpha subunit subtype of GABAA determines the efficacy, but not the potency, of AFX neuroactive steroid to potentiate IGABA.