IWR-1

• Catalog No.: I0161
• M. F.: C25H19N3O3
• M. W.: 409.43666
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-[(1R,2S,6R,7S)-3,5-dioxo-4-azatricyclo[5.2.1.0^2,^6]dec-8-en-4-yl]-N-(quinolin-8-yl)benzamide
• IUPAC Traditional name: iwr-1-endo
• Synonyms: IWR1; 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-Benzamide

PROPERTIES

• Empirical Formula (Hill Notation): C25H19N3O3
• Purity: ≥98% (HPLC)
• Apperance: tan
• Solubility: DMSO: ≥10 mg/mL
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
The Wnt/b-catenin (‘canonical’) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b).

Description (简体中文)

Biochem/physiol Actions
The Wnt/b-catenin (‘canonical’) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b).