Golgicide A

• Catalog No.: G0923
• CAS Number: 1005036-73-6
• M. F.: C17H14F2N2
• M. W.: 284.3032664
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 3-[(3aR,9bS)-6,8-difluoro-3H,3aH,4H,5H,9bH-cyclopenta[c]quinolin-4-yl]pyridine
• IUPAC Traditional name: 3-[(3aR,9bS)-6,8-difluoro-3H,3aH,4H,5H,9bH-cyclopenta[c]quinolin-4-yl]pyridine
• Synonyms: GCA; CID 25113626; 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

DATABASE IDS

• CAS Number: 1005036-73-6

PROPERTIES

• Empirical Formula (Hill Notation): C17H14F2N2
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H319
• GHS Precautionary statements: P305 + P351 + P338
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.

Description (简体中文)

Biochem/physiol Actions
Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.