Aristolochic acid I

• Catalog No.: A5512
• CAS Number: 313-67-7
• M. F.: C17H11NO7
• M. W.: 341.27174

SYNONYMS

• IUPAC name: 6-methoxy-9-nitro-14,16-dioxatetracyclo[8.7.0.0^2,^7.0^1^3,^1^7]heptadeca-1(17),2,4,6,8,10,12-heptaene-11-carboxylic acid
• IUPAC Traditional name: birthwort
• Synonyms: TR 1736

DATABASE IDS

• MDL Number: MFCD00004996
• CAS Number: 313-67-7
• EC Number: 206-238-3
• PubChem SID: 24890982

PROPERTIES

• Empirical Formula (Hill Notation): C17H11NO7
• Apperance: yellow powder
• Solubility: DMSO: soluble
• Solubility: ethanol: soluble
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 1544 6.1/PG 3
• Risk Statements: 25
• RTECS: CF3325000
• Safety Statements: 7-35-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Potent phospholipase A2 inhibitor, including calcium ionophore-induced phospholipase A2 activity in neutrophils. Kidney tumor initiator in experimental animal model.1
Application
Aristolochic acid I is a potent phospholipase A2 inhibitor. Aristolochic acid I induces tumor formation in rat kidneys and apoptosis in human renal proximal tubular epithelial cells.

Description (简体中文)

Biochem/physiol Actions
Potent phospholipase A2 inhibitor, including calcium ionophore-induced phospholipase A2 activity in neutrophils. Kidney tumor initiator in experimental animal model.1
Application
Aristolochic acid I is a potent phospholipase A2 inhibitor. Aristolochic acid I induces tumor formation in rat kidneys and apoptosis in human renal proximal tubular epithelial cells.