Colchicine

• Catalog No.: C9754
• CAS Number: 64-86-8
• M. F.: C22H25NO6
• M. W.: 399.437
• Purity: ≥95% (HPLC)

SYNONYMS

• Title: 秋水仙素
• IUPAC name: N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
• IUPAC Traditional name: colchicine

DATABASE IDS

• MDL Number: MFCD00078484
• Beilstein Number: 2228813
• PubChem SID: 24278348
• CAS Number: 64-86-8
• EC Number: 200-598-5

PROPERTIES

• Empirical Formula (Hill Notation): C22H25NO6
• Purity: ≥95% (HPLC)
• Gene Information: human ... ABCB1(5243), CYP3A4(1576)mouse ... Abcb1a(18671), Abcb1b(18669)
• Apperance: white to yellow powder
• Melting Point: 150-160 °C (dec.)(lit.)
• Solubility: ethanol: soluble50 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H300 + H330-H318-H340
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P260-P264-P280-P284-P301 + P310
• RID/ADR: UN 1544 6.1/PG 1
• Risk Statements: 46-28
• RTECS: GH0700000
• Safety Statements: 53-45
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Packaging
1, 5 g in poly bottle
100, 500 mg in poly bottle
Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Description (简体中文)

包装
1, 5 g in poly bottle
100, 500 mg in poly bottle
Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.