Colchicine

• Catalog No.: C3915
• CAS Number: 64-86-8
• M. F.: C22H25NO6
• M. W.: 399.437
• Purity: ≥95% (HPLC)

SYNONYMS

• Title: 秋水仙素
• IUPAC name: N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
• IUPAC Traditional name: colchicine

DATABASE IDS

• PubChem SID: 24892656
• MDL Number: MFCD00078484
• Beilstein Number: 2228813
• CAS Number: 64-86-8
• EC Number: 200-598-5

PROPERTIES

• GHS Signal Word: Danger
• GHS Hazard statements: H300 + H330-H318-H340
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P260-P264-P280-P284-P301 + P310
• RID/ADR: UN 1544 6.1/PG 1
• Risk Statements: 46-28
• RTECS: GH0700000
• Safety Statements: 53-45
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 1
• German water hazard class: 3
• Empirical Formula (Hill Notation): C22H25NO6
• Product Line: BioReagent
• Purity: ≥95% (HPLC)
• Suitability: plant cell culture tested
• Gene Information: human ... ABCB1(5243), CYP3A4(1576)mouse ... Abcb1a(18671), Abcb1b(18669)
• Melting Point: 150-160 °C (dec.)(lit.)

DETAILS

Description (English)

Biochem/physiol Actions
Colchicine is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, Colchicine is used to induce polyploidy (tetraploid) in plant cells.

Description (简体中文)

Biochem/physiol Actions
Colchicine is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, Colchicine is used to induce polyploidy (tetraploid) in plant cells.