Aconitine

• Catalog No.: A8001
• CAS Number: 302-27-2
• M. F.: C34H47NO11
• M. W.: 645.73708
• Purity: ≥95% (HPLC)

SYNONYMS

• Title: 乌头碱
• IUPAC name: (2R,3R,4R,5R,6S,7S,8R,9R,10S,13R,14R,16R,18R)-8-(acetyloxy)-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.1^2,^5.0^1,^1^0.0^3,^8.0^1^3,^1^7]nonadecan-4-yl benzoate
• IUPAC Traditional name: (2R,3R,4R,5R,6S,7S,8R,9R,10S,13R,14R,16R,18R)-8-(acetyloxy)-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.1^2,^5.0^1,^1^0.0^3,^8.0^1^3,^1^7]nonadecan-4-yl benzoate
• Synonyms: Acetylbenzoylaconine; 乙酰苯甲酰阿康碱

DATABASE IDS

• EC Number: 206-121-7
• PubChem SID: 24891304
• MDL Number: MFCD00082375
• Beilstein Number: 74608
• CAS Number: 302-27-2

PROPERTIES

• Empirical Formula (Hill Notation): C34H47NO11
• Purity: ≥95% (HPLC)
• Apperance: white crystalline
• Solubility: H2O: soluble0.3 mg/mL
• Solubility: ethanol: soluble35 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H330
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P260-P264-P284-P310
• RID/ADR: UN 1544 6.1/PG 1
• Risk Statements: 26/28
• RTECS: AR5960000
• Safety Statements: 24-45
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 1
• German water hazard class: 2

DETAILS

Description (English)

Application
Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.
Biochem/physiol Actions
Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.

Description (简体中文)

Application
Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.
Biochem/physiol Actions
Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.