SB 203580

• Catalog No.: S8307
• CAS Number: 152121-47-6
• M. F.: C21H16FN3OS
• M. W.: 377.4346432
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine
• IUPAC Traditional name: 4-[5-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-3H-imidazol-4-yl]pyridine
• Synonyms: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole

DATABASE IDS

• MDL Number: MFCD00922198
• CAS Number: 152121-47-6
• PubChem SID: 24899788

PROPERTIES

• Empirical Formula (Hill Notation): C21H16FN3OS
• Purity: ≥98% (HPLC)
• Gene Information: human ... CYP1A2(1544), CYP2C19(1557), CYP2C9(1559), CYP2D6(1565), CYP3A4(1576), IL1B(3553), MAPK14(1432), MAPK8IP2(23542), RAF1(5894), TNF(7124)
• Apperance: white to off-white solid
• Solubility: DMSO: ≥20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H318
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280-P305 + P351 + P338
• Risk Statements: 22-41
• Safety Statements: 26-39
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
SB 203580 is a pyridinyl imidazole that suppresses the activation of MAPKAP kinase-2 and inhibits the phosphorylation of heat shock protein (HSP) 27 in response to IL-1, cellular stresses and bacterial endotoxin in vivo. It does not inhibit JNK or p42 MAP kinase and therefore, is useful for studying the physiological roles and targets of p38 MAPK and MAPKAP kinase-2. It has been shown to induce the activation of the serine/threonine kinase Raf-1 and has been reported to inhibit cytokine production.

Description (简体中文)

Biochem/physiol Actions
SB 203580 is a pyridinyl imidazole that suppresses the activation of MAPKAP kinase-2 and inhibits the phosphorylation of heat shock protein (HSP) 27 in response to IL-1, cellular stresses and bacterial endotoxin in vivo. It does not inhibit JNK or p42 MAP kinase and therefore, is useful for studying the physiological roles and targets of p38 MAPK and MAPKAP kinase-2. It has been shown to induce the activation of the serine/threonine kinase Raf-1 and has been reported to inhibit cytokine production.