Nikkomycin Z from Streptomyces tendae

• Catalog No.: N8028
• CAS Number: 59456-70-1
• M. F.: C20H25N5O10
• M. W.: 495.44
• Purity: ≥90% (HPLC)

SYNONYMS

• IUPAC name: (2R)-2-[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanamido]-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid
• IUPAC Traditional name: (R)-[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanamido][(2R,3S,4R,5R)-5-(2,4-dioxo-3H-pyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid

DATABASE IDS

• CAS Number: 59456-70-1
• MDL Number: MFCD00869648
• PubChem SID: 24897849

PROPERTIES

• Empirical Formula (Hill Notation): C20H25N5O10
• Purity: ≥90% (HPLC)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: BA2928200
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species1 and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure2.
Biochem/physiol Actions
Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine3. Nikkomycin Z has potent antifungal, insecticidal and acaridicial activity.

Description (简体中文)

Application
Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species1 and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure2.
Biochem/physiol Actions
Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine3. Nikkomycin Z has potent antifungal, insecticidal and acaridicial activity.