GF 109203X

• Catalog No.: G2911
• CAS Number: 133052-90-1
• M. F.: C25H24N4O2
• M. W.: 412.48366
• Purity: ≥90% (HPLC)

SYNONYMS

• IUPAC name: 3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
• IUPAC Traditional name: bisindolylmaleimide
• Synonyms: 3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide; 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione; Bisindolylmaleimide I

DATABASE IDS

• MDL Number: MFCD00236428
• CAS Number: 133052-90-1

PROPERTIES

• Biological Source: synthetic
• Empirical Formula (Hill Notation): C25H24N4O2
• Purity: ≥90% (HPLC)
• Solubility: DMSO: soluble (~1 mg/ml)
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 40
• Safety Statements: 36/37
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.1
Quantity
For PKC inhibition, typically used at a concentration of 0.1-10 μM.

Description (简体中文)

Biochem/physiol Actions
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.1
Quantity
For PKC inhibition, typically used at a concentration of 0.1-10 μM.